JJAZ1 (joined to JAZF1)
نویسندگان
چکیده
منابع مشابه
Diagnostic Utility of the JAZF1/JJAZ1 Gene Fusion in Endometrial Stromal Sarcomas and Their Histologic Variants
Endometrial stromal tumor is an uncommon uterine tumor comprising <10% of all uterine mesenchymal neoplasms. The diagnosis of low-grade endometrial stromal sarcoma (LGESS) is based on characteristic histopathological features showing diffuse growth of uniform stromal cells resembling those of proliferative phase endometrium and uniformly distributed small spiral arterioles and it is not problem...
متن کاملCytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17).
Endometrial stromal sarcomas (ESS) are rare neoplasms with the capacity both to invade the myometrium locally and to give rise to extrauterine metastases. Cytogenetic abnormalities have been reported in 22 cases of ESS, mostly involving rearrangements of chromosomes 6, 7, and 17. The most characteristic translocation of this tumor type, t(7;17)(p15 approximately p21;q12 approximately q21), was ...
متن کاملConsistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
Endometrial stromal sarcomas (ESS) represent <10% of all uterine sarcomas. Cytogenetic data on this tumor type are limited to 32 cases, and the karyotypes are often complex, but the pattern of rearrangement is nevertheless clearly nonrandom with particularly frequent involvement of chromosome arms 6p and 7p. Recently, a specific translocation t(7;17)(p15;q21) leading to the fusion of two zinc f...
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Cooperation in the cerebellum y crossing knockout mice deficient for two cell adhesion molecules, Sakurai et al. have obtained the first genetic evidence for the molecules' functional overlap, and have explained why earlier tissue culture results were not replicated in single knockout mice (page 1259). Sakurai and colleagues started by engineering mice deficient for NrCAM, which had only mild (...
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Australia is embarking on an ambitious scheme described as a terrestrial version of the Great Barrier Reef, to establish a wildlife corridor along its 2,800-kilometre east coast to help protect the country's remarkable wildlife from potential climate change. The project aims to re-establish a network of habitats from the Australian Alps in the southern state of Victoria to the Atherton tablelan...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38312